In 1787, the Northwest Ordinance officially organized the Northwest Territory for white settlement. American settlers began pouring into the region. Violence erupted as Indians resisted this encroachment, and so the administration of President George Washington sent armed expeditions into the area to put down native resistance. However, in the Northwest Indian War, a pan-tribal confederacy led by Blue Jacket (Shawnee), Little Turtle (Miami), Buckongahelas (Lenape), and Egushawa (Ottawa) crushed armies led by Generals Josiah Harmar and Arthur St. Clair. General St. Clair’s defeat was the most severe loss ever inflicted upon an American army by Native Americans.
The Americans attempted to negotiate a settlement, but Blue Jacket and the Shawnee-led confederacy insisted on a boundary line the Americans found unacceptable, and so a new expedition led by General Anthony Wayne was dispatched. Wayne’s army defeated the Indian confederacy at the Battle of Fallen Timbers in 1794. The Indians had hoped for British assistance; when that was not forthcoming, the Indians were compelled to sign the Treaty of Greenville in 1795, which ceded modern-day Ohio and part of Indiana to the United States.